Journal article
Prevention and amelioration of collagen-induced arthritis by blockade of the CD28 co-stimulatory pathway: requirement for both B7-1 and B7-2.
- Abstract:
-
Collagen type II-induced arthritis (CIA) is an experimental model of arthritis that has been successfully used to dissect the pathogenesis of human rheumatoid arthritis and to identify potential therapeutic targets. We have used this model to evaluate the role of T cell co-stimulation in both disease development and progression. T cell co-stimulation is provided by ligation of CD28 with either B7-1 or B7-2 present on antigen-presenting cells and can be prevented by a soluble form of CTLA-4 (C...
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- Publication status:
- Published
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- Publisher copy:
- 10.1002/eji.1830261008
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Authors
Bibliographic Details
- Journal:
- European journal of immunology
- Volume:
- 26
- Issue:
- 10
- Pages:
- 2320-2328
- Publication date:
- 1996-10-01
- DOI:
- EISSN:
-
1521-4141
- ISSN:
-
0014-2980
- Source identifiers:
-
481620
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:481620
- UUID:
-
uuid:383179df-f8de-43af-9cd6-9791cddcbe80
- Local pid:
- pubs:481620
- Deposit date:
- 2014-08-29
Terms of use
- Copyright date:
- 1996
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