Journal article
Ocular pharmacokinetics of therapeutic antibodies given by intravitreal injection: estimation of retinal permeabilities using a 3-compartment semi-mechanistic model
- Abstract:
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Intravitreally (IVT) injected macromolecules for the treatment of age-related macular degeneration must permeate through the inner limiting membrane (ILM) into the retina and through the retinal pigment epithelium (RPE) to enter the choroid. A quantitative understanding of intraocular transport mechanisms, elimination pathways and the effect of molecular size, is currently incomplete. We present a semi-mechanistic, 3-compartment (retina, vitreous and aqueous) pharmacokinetic (PK) model, expre...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Accepted manuscript, pdf, 1.5MB)
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- Publisher copy:
- 10.1021/acs.molpharmaceut.7b00164
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Authors
Funding
Roche Pharma Research and Early Development
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Bibliographic Details
- Publisher:
- American Chemical Society Publisher's website
- Journal:
- Molecular Pharmaceutics Journal website
- Volume:
- 14
- Issue:
- 8
- Pages:
- 2690–2696
- Publication date:
- 2017-06-20
- Acceptance date:
- 2017-06-20
- DOI:
- EISSN:
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1543-8392
- ISSN:
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1543-8384
- Source identifiers:
-
701747
Item Description
- Keywords:
- Pubs id:
-
pubs:701747
- UUID:
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uuid:38328de4-911a-4a9f-8e2b-0a1c64416877
- Local pid:
- pubs:701747
- Deposit date:
- 2017-06-23
Terms of use
- Copyright holder:
- American Chemical Society
- Copyright date:
- 2017
- Notes:
- Copyright © 2017 American Chemical Society. This is the accepted manuscript version of the article. The final version is available online from American Chemical Society at: https://doi.org/10.1021/acs.molpharmaceut.7b00164
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