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Ocular pharmacokinetics of therapeutic antibodies given by intravitreal injection: estimation of retinal permeabilities using a 3-compartment semi-mechanistic model

Abstract:

Intravitreally (IVT) injected macromolecules for the treatment of age-related macular degeneration must permeate through the inner limiting membrane (ILM) into the retina and through the retinal pigment epithelium (RPE) to enter the choroid. A quantitative understanding of intraocular transport mechanisms, elimination pathways and the effect of molecular size, is currently incomplete. We present a semi-mechanistic, 3-compartment (retina, vitreous and aqueous) pharmacokinetic (PK) model, expre...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1021/acs.molpharmaceut.7b00164

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Institution:
University of Oxford
Division:
MPLS
Department:
Mathematical Institute
Role:
Author
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Institution:
University of Oxford
Oxford college:
Brasenose College
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Mathematical Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Mathematical Institute
Role:
Author
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Roche Pharma Research and Early Development More from this funder
Publisher:
American Chemical Society Publisher's website
Journal:
Molecular Pharmaceutics Journal website
Volume:
14
Issue:
8
Pages:
2690–2696
Publication date:
2017-06-20
Acceptance date:
2017-06-20
DOI:
EISSN:
1543-8392
ISSN:
1543-8384
Source identifiers:
701747
Keywords:
Pubs id:
pubs:701747
UUID:
uuid:38328de4-911a-4a9f-8e2b-0a1c64416877
Local pid:
pubs:701747
Deposit date:
2017-06-23

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