Thesis
Novel adenovirus vaccine vectors
- Abstract:
-
Replication defective adenoviruses have emerged as promising vectors for delivery of vaccine antigens. The development of new vaccine vectors has recently focused on serotypes to which the human population is less exposed in order to circumvent pre-existing anti vector immunity. This thesis describes the construction and optimisation of ChAdOX1, a new vector based on chimpanzee adenovirus Y25, which has recently been manufactured to clinical grade for a Phase I human trial.
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Authors
Contributors
+ Hill, A
Division:
MSD
Department:
NDM
Role:
Supervisor
+ Gilbert, S
Division:
MSD
Department:
NDM
Role:
Supervisor
+ Spencer, A
Division:
MSD
Department:
NDM
Role:
Supervisor
+ Cottingham, M
Division:
MSD
Department:
NDM
Role:
Supervisor
Bibliographic Details
- Publication date:
- 2013
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:383aaf3d-284a-4bd7-877c-3270bd7c2e4f
- Local pid:
- ora:12361
- Deposit date:
- 2015-11-30
Terms of use
- Copyright holder:
- Dicks, M
- Copyright date:
- 2013
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