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Thesis

Investigating the neurochemistry of depression and the novel mood stabilising agent, ebselen, using magnetic resonance spectroscopy

Alternative title:
Neurochemistry of depression and the novel mood stabilizing agent ebselen
Abstract:

RATIONALE: Magnetic resonance spectroscopy (MRS) offers a tool for investigating in vivo neurochemical changes in depression, as well as for guiding targeted drug development. Using MRS, changes to the glutamatergic system have been demonstrated in depressed patients, although results from different studies have often been inconsistent. Elucidating the role of glutamate in depression can be helped by carrying out assessment with ultra-high field MRS and in addition to this, identifying pat...

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Institution:
University of Oxford
Oxford college:
Oriel College
Role:
Author

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Supervisor
Role:
Supervisor
Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
UUID:
uuid:383bdb4b-0fe9-408a-ba8c-fe3a226030aa
Deposit date:
2017-10-21

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