Journal article
Modulation of the ligand binding properties of the transcription repressor NmrA by GATA-containing DNA and site-directed mutagenesis.
- Abstract:
-
NmrA is a negative transcription-regulating protein that binds to the C-terminal region of the GATA transcription-activating protein AreA. The proposed molecular mechanism of action for NmrA is to inhibit AreA binding to its target promoters. In contrast to this proposal, we report that a C-terminal fragment of AreA can bind individually to GATA-containing DNA and NmrA and that in the presence of a mixture of GATA-containing DNA and NmrA, the AreA fragment binds preferentially to the GATA-con...
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- Publication status:
- Published
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- Publisher copy:
- 10.1110/ps.04958904
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Authors
Bibliographic Details
- Journal:
- Protein science : a publication of the Protein Society
- Volume:
- 13
- Issue:
- 12
- Pages:
- 3127-3138
- Publication date:
- 2004-12-01
- DOI:
- EISSN:
-
1469-896X
- ISSN:
-
0961-8368
- Source identifiers:
-
72624
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:72624
- UUID:
-
uuid:384eedb0-09cc-4c8a-b113-31ec4c7afb44
- Local pid:
- pubs:72624
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2004
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