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Modulation of the ligand binding properties of the transcription repressor NmrA by GATA-containing DNA and site-directed mutagenesis.

Abstract:

NmrA is a negative transcription-regulating protein that binds to the C-terminal region of the GATA transcription-activating protein AreA. The proposed molecular mechanism of action for NmrA is to inhibit AreA binding to its target promoters. In contrast to this proposal, we report that a C-terminal fragment of AreA can bind individually to GATA-containing DNA and NmrA and that in the presence of a mixture of GATA-containing DNA and NmrA, the AreA fragment binds preferentially to the GATA-con...

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Publication status:
Published

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Publisher copy:
10.1110/ps.04958904

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Journal:
Protein science : a publication of the Protein Society
Volume:
13
Issue:
12
Pages:
3127-3138
Publication date:
2004-12-01
DOI:
EISSN:
1469-896X
ISSN:
0961-8368
Source identifiers:
72624
Language:
English
Keywords:
Pubs id:
pubs:72624
UUID:
uuid:384eedb0-09cc-4c8a-b113-31ec4c7afb44
Local pid:
pubs:72624
Deposit date:
2012-12-19

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