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Enhanced T cell-mediated protection against malaria in human challenges by using the recombinant poxviruses FP9 and modified vaccinia virus Ankara.

Abstract:

Malaria is a major global health problem for which an effective vaccine is required urgently. Prime-boost vaccination regimes involving plasmid DNA and recombinant modified vaccinia virus Ankara-encoding liver-stage malaria antigens have been shown to be powerfully immunogenic for T cells and capable of inducing partial protection against experimental malaria challenge in humans, manifested as a delay in time to patent parasitemia. Here, we report that substitution of plasmid DNA as the primi...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.0406381102

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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
102
Issue:
13
Pages:
4836-4841
Publication date:
2005-03-01
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Source identifiers:
33033

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