Journal article
Evolutionary diversification of the trypanosome haptoglobin-haemoglobin receptor from an ancestral haemoglobin receptor.
- Abstract:
-
The haptoglobin-haemoglobin receptor of the African trypanosome species, Trypanosoma brucei, is expressed when the parasite is in the bloodstream of the mammalian host, allowing it to acquire haem through the uptake of haptoglobin-haemoglobin complexes. Here we show that in Trypanosoma congolense this receptor is instead expressed in the epimastigote developmental stage that occurs in the tsetse fly, where it acts as a haemoglobin receptor. We also present the structure of the T. congolense r...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Authors
Funding
+ Wellcome Trust
More from this funder
Funding agency for:
Lane-Serff, H
Grant:
PhD program in Structural Biology
+ Medical Research Council
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Funding agency for:
Higgins, M
Carrington, M
Grant:
MR/L008246
MR/L008246
Bibliographic Details
- Publisher:
- eLife Sciences Publications Publisher's website
- Journal:
- eLife Journal website
- Volume:
- 5
- Publication date:
- 2016-04-15
- Acceptance date:
- 2016-04-14
- DOI:
- EISSN:
-
2050-084X
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:616799
- UUID:
-
uuid:385b8f89-6f58-4e02-9007-75ea6520af54
- Local pid:
- pubs:616799
- Source identifiers:
-
616799
- Deposit date:
- 2016-04-21
Terms of use
- Copyright holder:
- Lane-Serff et al
- Copyright date:
- 2016
- Notes:
- © 2016, Lane-Serff et al. This article is distributed under the terms of the Creative Commons Attribution License.
- Licence:
- CC Attribution (CC BY)
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