Journal article icon

Journal article

The origin of B-cells: human fetal B cell development and implications for the pathogenesis of childhood acute lymphoblastic leukemia

Abstract:

Human B-lymphopoiesis is a dynamic life-long process that starts in utero by around six post-conception weeks. A detailed understanding of human fetal B-lymphopoiesis and how it changes in postnatal life is vital for building a complete picture of normal B-lymphoid development through ontogeny, and its relevance in disease. B-cell acute lymphoblastic leukemia (B-ALL) is one of the most common cancers in children, with many of the leukemia-initiating events originating in utero. It is likely t...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.3389/fimmu.2021.637975

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Sub department:
Paediatrics
Role:
Author
ORCID:
0000-0001-8607-5748
Publisher:
Frontiers Media Publisher's website
Journal:
Frontiers in Immunology Journal website
Volume:
12
Article number:
637975
Publication date:
2021-02-17
Acceptance date:
2021-01-28
DOI:
EISSN:
1664-3224
Language:
English
Keywords:
Pubs id:
1163665
Local pid:
pubs:1163665
Deposit date:
2021-02-26

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP