Thesis
The characterization and engineering of human antigen-specific cytotoxic T cells
- Abstract:
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This D.Phil. thesis focuses on human antigen-specific cytotoxic T lymphocytes (CTLs). In the first part of the thesis, the impact of antigen stimulation strength on CTL activation was investigated by evaluating the global transcriptomes of a wellcharacterized CTL clone and some of its surface protein expressions, with particular focus on immune checkpoint receptors. Based on the gene differentiations, an 'EGR2-CCL1-4-1BB' pathway, which is sensitive to very low-strength antigen stimu...
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Bibliographic Details
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- UUID:
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uuid:38718489-9fa3-4fa5-b50d-547ccc9adeed
- Deposit date:
- 2017-11-09
Terms of use
- Copyright holder:
- Zhang, C
- Copyright date:
- 2017
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