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The architecture and ppGpp-dependent expression of the primary transcriptome of Salmonella Typhimurium during invasion gene expression.

Abstract:

BACKGROUND: Invasion of intestinal epithelial cells by Salmonella enterica serovar Typhimurium (S. Typhimurium) requires expression of the extracellular virulence gene expression programme (ST(EX)), activation of which is dependent on the signalling molecule guanosine tetraphosphate (ppGpp). Recently, next-generation transcriptomics (RNA-seq) has revealed the unexpected complexity of bacterial transcriptomes and in this report we use differential RNA sequencing (dRNA-seq) to define the high-...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/1471-2164-13-25

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Institution:
University of Oxford
Role:
Author
Publisher:
BioMed Central Publisher's website
Journal:
BMC genomics Journal website
Volume:
13
Issue:
1
Pages:
25
Publication date:
2012-01-01
DOI:
EISSN:
1471-2164
ISSN:
1471-2164
Source identifiers:
411570

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