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The road to avibactam: The first clinically useful non-β-lactam working somewhat like a β-lactam

Abstract:

Avibactam, which is the first non-β-lactam β-lactamase inhibitor to be introduced for clinical use, is a broad-spectrum serine β-lactamase inhibitor with activity against class A, class C, and, some, class D β-lactamases. We provide an overview of efforts, which extend to the period soon after the discovery of the penicillins, to develop clinically useful non-β-lactam compounds as antibacterials, and, subsequently, penicillin-binding protein and β-lactamase inhibitors. Like the β-lactam inhib...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.4155/fmc-2016-0078

Authors


More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Chemistry Research Laboratory
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Chemistry Research Laboratory
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Chemistry Research Laboratory
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Chemistry Research Laboratory
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Chemistry Research Laboratory
Role:
Author
Biotechnology and Biological Sciences Research Council More from this funder
Biochemical Society More from this funder
AstraZeneca, More from this funder
Publisher:
Future Science Ltd Publisher's website
Journal:
Future Medicinal Chemistry Journal website
Volume:
8
Issue:
10
Pages:
1063-1084
Publication date:
2016-06-01
Acceptance date:
2016-05-06
DOI:
EISSN:
1756-8927
ISSN:
1756-8919
Source identifiers:
631143
Language:
English
Keywords:
Pubs id:
pubs:631143
UUID:
uuid:387bb618-ff2e-4cbb-adc2-d38cb9d37ac6
Local pid:
pubs:631143
Deposit date:
2016-08-16

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