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CD8+ Tc2 cells: underappreciated contributors to severe asthma

Abstract:

The complexity of asthma is underscored by the number of cell types and mediators implicated in the pathogenesis of this heterogeneous syndrome. Type 2 CD4+ T-cells (Th2) and more recently, type 2 innate lymphoid cells dominate current descriptions of asthma pathogenesis. However, another important source of these type 2 cytokines, especially interleukin (IL)-5 and IL-13, are CD8+ T-cells, which are increasingly proposed to play an important role in asthma pathogenesis, because they are abund...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1183/16000617.0092-2019

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
ORCID:
0000-0003-0699-2373
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
NIHR Oxford Biomedical Research Centre More from this funder
Medical Research Council More from this funder
Publisher:
European Respiratory Society Publisher's website
Journal:
European Respiratory Review Journal website
Volume:
28
Issue:
154
Article number:
190092
Publication date:
2019-11-20
Acceptance date:
2019-07-29
DOI:
EISSN:
1600-0617
ISSN:
0905-9180
Source identifiers:
1036062
Keywords:
Pubs id:
pubs:1036062
UUID:
uuid:38870b15-c043-4695-882c-e4d2e54f031e
Local pid:
pubs:1036062
Deposit date:
2019-07-29

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