Journal article icon

Journal article

Tumour necrosis factor synergises with gamma interferon on the induction of mRNA for DR alpha chain on thyrocytes from Graves' disease and non toxic goitre.

Abstract:

In both thyroid autoimmune diseases Graves' and Hashimoto's thyroiditis, the epithelial thyroid follicular cells (TFC) have been shown to express HLA class II molecules, and can restimulate autoreactive T cells cloned from the diseased tissue. This aberrant class II expression is important in the mechanism of perpetuation of the disease process, therefore we have compared the effect of interferon gamma (IFN gamma) and tumour necrosis factor (TNF alpha) on the HLA-DR alpha mRNA expression of t...

Expand abstract

Actions


Access Document


Publisher copy:
10.3109/08916938909014702

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
Publisher:
Informa Healthcare
Journal:
Autoimmunity
Volume:
4
Issue:
4
Pages:
255-266
Publication date:
1989-01-01
DOI:
EISSN:
1607-842X
ISSN:
0891-6934
Source identifiers:
481776
Language:
English
Keywords:
Pubs id:
pubs:481776
UUID:
uuid:3887b53c-b810-4b6c-853d-825b2166eb46
Local pid:
pubs:481776
Deposit date:
2014-08-29

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP