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Thesis

The localization and functional analysis

Abstract:

Nicotinic acid adenine dinucleotide phosphate (NAADP) is the most recently characterized Ca2+ mobilizing second messenger, joining inositol 1,4,5-trisphosphate (IP3) and cyclic ADP-ribose (cADPR). Previous pharmacological and biochemical studies have suggested that NAADP targets acidic Ca2+ stores rather than the ER, which releases Ca2+ in response to IP3 or cADPR. Although NAADP receptors are proposed to be distinct from those for IP3 and cADPR, the molecular identity of NAADP receptors...

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Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author

Contributors

Division:
MSD
Department:
Pharmacology
Role:
Supervisor
Division:
MSD
Department:
Pharmacology
Role:
Supervisor
Publication date:
2011
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:38955a51-7f18-4456-b916-8c896b9ee23a
Deposit date:
2016-11-15

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