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Journal article

Inflammatory stroke extracellular vesicles induce macrophage activation

Abstract:

BACKGROUND AND PURPOSE: Extracellular vesicles (EVs) are protein-lipid complexes released from cells, as well as actively exocytosed, as part of normal physiology, but also during pathological processes such as those occurring during a stroke. Our aim was to determine the inflammatory potential of stroke EVs. METHODS: EVs were quantified and analyzed in the sera of patients after an acute stroke (<24 hours; OXVASC [Oxford Vascular Study]). Isolated EV fractions were subjected to untargeted...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1161/STROKEAHA.117.017236

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM - Investigative Medicine Division
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Target Discovery Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Target Discovery Institute
Role:
Author
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Publisher:
American Heart Association Publisher's website
Journal:
Stroke Journal website
Volume:
48
Issue:
8
Pages:
2292-2296
Publication date:
2017-05-23
Acceptance date:
2017-04-14
DOI:
EISSN:
1524-4628
ISSN:
0039-2499
Source identifiers:
697730
Language:
English
Keywords:
Pubs id:
pubs:697730
UUID:
uuid:38a76e13-ff49-47dc-a580-3ecbae70da6c
Local pid:
pubs:697730
Deposit date:
2017-07-11

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