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A hybrid approach to multi−scale modelling of cancer

Abstract:

In this paper, we review multi-scale models of solid tumour growth and discuss a middleout framework that tracks individual cells. By focusing on the cellular dynamics of a healthy colorectal crypt and its invasion by mutant, cancerous cells, we compare a cellcentre, a cell-vertex and a continuum model of cell proliferation and movement. All models reproduce the basic features of a healthy crypt: cells proliferate near the crypt base, they migrate upwards and are sloughed off near the top. Th...

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Publisher copy:
10.1098/rsta.2010.0173

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Journal:
Philosophical Transactions of the Royal Society A: Mathematical‚ Physical and Engineering Sciences
Volume:
368
Issue:
1930
Pages:
5013-5028
Publication date:
2010-11-01
DOI:
UUID:
uuid:38b0dd4b-882b-4985-9d33-96b9ae46db89
Local pid:
cs:5034
Deposit date:
2015-03-31

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