Journal article
A hybrid approach to multi−scale modelling of cancer
- Abstract:
-
In this paper, we review multi-scale models of solid tumour growth and discuss a middleout framework that tracks individual cells. By focusing on the cellular dynamics of a healthy colorectal crypt and its invasion by mutant, cancerous cells, we compare a cellcentre, a cell-vertex and a continuum model of cell proliferation and movement. All models reproduce the basic features of a healthy crypt: cells proliferate near the crypt base, they migrate upwards and are sloughed off near the top. Th...
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- Publisher copy:
- 10.1098/rsta.2010.0173
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Authors
Bibliographic Details
- Journal:
- Philosophical Transactions of the Royal Society A: Mathematical‚ Physical and Engineering Sciences
- Volume:
- 368
- Issue:
- 1930
- Pages:
- 5013-5028
- Publication date:
- 2010-11-01
- DOI:
Item Description
- UUID:
-
uuid:38b0dd4b-882b-4985-9d33-96b9ae46db89
- Local pid:
- cs:5034
- Deposit date:
- 2015-03-31
Terms of use
- Copyright date:
- 2010
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