Journal article icon

Journal article

Using siRNA to define functional interactions between melanopsin and multiple G Protein partners.

Abstract:

Melanopsin expressing photosensitive retinal ganglion cells (pRGCs) represent a third class of ocular photoreceptors and mediate a range of non-image forming responses to light. Melanopsin is a G protein coupled receptor (GPCR) and existing data suggest that it employs a membrane bound signalling cascade involving Gnaq/11 type G proteins. However, to date the precise identity of the Gα subunits involved in melanopsin phototransduction remains poorly defined. Here we show that Gnaq, Gna11 and ...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1007/s00018-014-1664-6

Authors


Expand authors...
Journal:
Cellular and molecular life sciences : CMLS
Volume:
72
Issue:
1
Pages:
165-179
Publication date:
2015-01-01
DOI:
EISSN:
1420-9071
ISSN:
1420-682X
Source identifiers:
470923

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP