Journal article icon

Journal article

Evaluation of phylogenetic reconstruction methods using bacterial whole genomes: a simulation based study

Abstract:

Background: Phylogenetic reconstruction is a necessary first step in many analyses which use whole genome sequence data from bacterial populations. There are many available methods to infer phylogenies, and these have various advantages and disadvantages, but few unbiased comparisons of the range of approaches have been made.

Methods: We simulated data from a defined “true tree” using a realistic evolutionary model. We built phylogenies from this data using a range of methods, and c...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.12688/wellcomeopenres.14265.2

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author
Expand authors...
More from this funder
Funding agency for:
Lees, JA
Grant:
1365620
More from this funder
Funding agency for:
Colijn, C
Grant:
EP/N014529/1
Publisher:
F1000 Research Publisher's website
Journal:
Wellcome Open Research Journal website
Volume:
3
Issue:
33
Pages:
1-17
Publication date:
2018-03-23
DOI:
ISSN:
2398-502X
Pubs id:
pubs:833449
UUID:
uuid:38bc202a-1ed8-4f49-b2bd-6c0f7503af23
Local pid:
pubs:833449
Deposit date:
2018-04-04

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP