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Journal article

Prophylactic and therapeutic efficacy of human monoclonal antibodies against H5N1 influenza.

Abstract:

BACKGROUND: New prophylactic and therapeutic strategies to combat human infections with highly pathogenic avian influenza (HPAI) H5N1 viruses are needed. We generated neutralizing anti-H5N1 human monoclonal antibodies (mAbs) and tested their efficacy for prophylaxis and therapy in a murine model of infection. METHODS AND FINDINGS: Using Epstein-Barr virus we immortalized memory B cells from Vietnamese adults who had recovered from infections with HPAI H5N1 viruses. Supernatants from B cell l...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pmed.0040178

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
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National Institute of Allergy and Infectious Diseases More from this funder
National Institutes of Health More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS medicine Journal website
Volume:
4
Issue:
5
Article number:
e178
Publication date:
2007-05-01
DOI:
EISSN:
1549-1676
ISSN:
1549-1277
Source identifiers:
92753

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