Journal article
Prophylactic and therapeutic efficacy of human monoclonal antibodies against H5N1 influenza.
- Abstract:
-
BACKGROUND: New prophylactic and therapeutic strategies to combat human infections with highly pathogenic avian influenza (HPAI) H5N1 viruses are needed. We generated neutralizing anti-H5N1 human monoclonal antibodies (mAbs) and tested their efficacy for prophylaxis and therapy in a murine model of infection. METHODS AND FINDINGS: Using Epstein-Barr virus we immortalized memory B cells from Vietnamese adults who had recovered from infections with HPAI H5N1 viruses. Supernatants from B cell l...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
National Institutes of Health
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National Institute of Allergy and Infectious Diseases
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Bibliographic Details
- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PLoS medicine Journal website
- Volume:
- 4
- Issue:
- 5
- Article number:
- e178
- Publication date:
- 2007-05-01
- DOI:
- EISSN:
-
1549-1676
- ISSN:
-
1549-1277
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:92753
- UUID:
-
uuid:38e40038-72fd-429e-8a6f-21d620480567
- Local pid:
- pubs:92753
- Source identifiers:
-
92753
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2007
- Notes:
- This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.
- Licence:
- CC Public Domain Dedication (CC0)
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