Unique patterns of glycosylation in immunoglobulin subclass G4‐related disease and primary sclerosing cholangitis
Background: Immunoglobulin subclass G4‐related disease (IgG4‐RD) is characterized by an abundance of IgG4 antibodies in the serum and tissue. Glycosylation status of antibodies can impact on immune effector functions and disease pathophysiology. We sought to establish glycosylation patterns in a prospective cohort of patients with IgG4‐RD and the relationship with disease activity and response to treatment.
Methods: We assessed IgG Fc‐tail and Fab‐arm glycosylation status in patien...Expand abstract
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- Culver, et al
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© 2018 The Authors Journal of Gastroenterology and Hepatology published by Journal of Gastroenterology and Hepatology Foundation and John Wiley and Sons Australia, Ltd
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