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The interaction of natural selection and GC skew may drive the fast evolution of a sand rat homeobox gene

Abstract:

Several processes can lead to strong GC skew in localized genomic regions. In most cases, GC skew should not affect conserved amino acids because natural selection will purge deleterious alleles. However, in the gerbil subfamily of rodents, several conserved genes have undergone radical alteration in association with strong GC skew. An extreme example concerns the highly conserved homeobox gene Pdx1, which is uniquely divergent and GC rich in the sand rat Psammomys obesus and close relatives....

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/molbev/msz080

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More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Zoology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Zoology
Oxford college:
Merton College
Role:
Author
ORCID:
0000-0003-1533-9376
Publisher:
Oxford University Press Publisher's website
Journal:
Molecular Biology and Evolution Journal website
Volume:
36
Issue:
7
Pages:
1473–1480
Publication date:
2019-04-09
Acceptance date:
2019-03-26
DOI:
EISSN:
1537-1719
ISSN:
0737-4038
Source identifiers:
987624
Language:
English
Keywords:
Pubs id:
pubs:987624
UUID:
uuid:390611f0-f394-4a7f-bdd3-d24b6cfd4cd0
Local pid:
pubs:987624
Deposit date:
2019-04-06

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