Journal article
Evolutionary repurposing of a sulfatase: A new Michaelis complex leads to efficient transition state charge offset
- Abstract:
-
The recruitment and evolutionary optimization of promiscuous enzymes is key to the rapid adaptation of organisms to changing environments. Our understanding of the precise mechanisms underlying enzyme repurposing is, however, limited: What are the active-site features that enable the molecular recognition of multiple substrates with contrasting catalytic requirements? To gain insights into the molecular determinants of adaptation in promiscuous enzymes, we performed the laboratory evolutio...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
Engineering and Physical Sciences Research Council
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Biotechnology and Biological Sciences Research Council
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Bibliographic Details
- Publisher:
- National Academy of Sciences Publisher's website
- Journal:
- Proceedings of the National Academy of Sciences Journal website
- Volume:
- 115
- Issue:
- 31
- Pages:
- E7293-E7302
- Publication date:
- 2018-07-16
- Acceptance date:
- 2018-05-31
- DOI:
- EISSN:
-
1091-6490
- ISSN:
-
0027-8424
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:974247
- UUID:
-
uuid:3918a8f6-5959-4e9c-930b-4360f2c0042a
- Local pid:
- pubs:974247
- Source identifiers:
-
974247
- Deposit date:
- 2019-07-23
Terms of use
- Copyright holder:
- Miton et al
- Copyright date:
- 2018
- Notes:
- Copyright 2019 The Author(s).
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