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Decoding voluntary movements and postural tremor based on thalamic LFPs as a basis for closed-loop stimulation for essential tremor

Abstract:

Background

High frequency Deep brain stimulation (DBS) targeting motor thalamus is an effective therapy for essential tremor (ET). However, conventional continuous stimulation may deliver unnecessary current to the brain since tremor mainly affects voluntary movements and sustained postures in ET.

Objective

We aim to decode both voluntary movements and the presence of postural tremor from the Local field potentials (LFPs) recorded from...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.brs.2019.02.011

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
ORCID:
0000-0001-8038-3029
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Surgical Sciences
Role:
Author
ORCID:
0000-0001-9128-8668
More from this funder
Funding agency for:
Huang, Y
He, S
Brown, P
Debarros, J
Tan, H
Aziz, T
Wang, S
Green, AL
Pedrosa, DJ
Timmermann, L
Visser-Vandewalle, V
Pogosyan, A
Huang, Y
He, S
Brown, P
Debarros, J
Tan, H
Aziz, T
Wang, S
Green, AL
Pedrosa, DJ
Timmermann, L
Visser-Vandewalle, V
Pogosyan, A
Grant:
MC_UU_12024/1
MR/P012272/1
More from this funder
Funding agency for:
Huang, Y
He, S
Brown, P
Debarros, J
Tan, H
Aziz, T
Wang, S
Green, AL
Pedrosa, DJ
Timmermann, L
Visser-Vandewalle, V
Pogosyan, A
More from this funder
Funding agency for:
Huang, Y
He, S
Brown, P
Debarros, J
Tan, H
Aziz, T
Wang, S
Green, AL
Pedrosa, DJ
Timmermann, L
Visser-Vandewalle, V
Pogosyan, A
Publisher:
Elsevier Publisher's website
Journal:
Brain Stimulation Journal website
Volume:
12
Issue:
4
Pages:
858-867
Publication date:
2019-02-20
Acceptance date:
2019-02-18
DOI:
ISSN:
1935-861X
Language:
English
Keywords:
Pubs id:
pubs:977492
UUID:
uuid:393fa5b8-572c-41e0-94da-e876a8460ea4
Local pid:
pubs:977492
Deposit date:
2019-02-28

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