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The role of activins in hepcidin regulation during malaria

Abstract:

Epidemiological observations have linked increased host iron with malaria susceptibility, and perturbed iron handling has been hypothesized to contribute to the potentially life threatening anemia that may accompany blood-stage malaria infection. To improve our understanding of these relationships, we examined the pathways involved in regulation of the master controller of iron metabolism, the hormone hepcidin, in malaria infection. We show that hepcidin upregulation in Plasmodium bergh...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1128/IAI.00191-17

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM - Investigative Medicine Division
Role:
Author
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Funding agency for:
Drakesmith, A
Grant:
MC_UU_12010/1
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Funding agency for:
Hodgson, S
Grant:
Research Training Fellowship (097940/Z/11/Z
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Funding agency for:
Drakesmith, A
Grant:
MC_UU_12010/1
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Funding agency for:
Drakesmith, A
Grant:
MC_UU_12010/1
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Funding agency for:
Draper, S
Grant:
Senior Fellowship (106917/Z/15/Z
Publisher:
American Society for Microbiology Publisher's website
Journal:
Infection and Immunity Journal website
Volume:
85
Issue:
12
Pages:
e00191-17
Publication date:
2017-09-11
Acceptance date:
2017-08-23
DOI:
EISSN:
1098-5522
ISSN:
0019-9567
Source identifiers:
725777
Pubs id:
pubs:725777
UUID:
uuid:3940ca96-861d-4e74-a328-abeb2cb11340
Local pid:
pubs:725777
Deposit date:
2017-09-07

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