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Journal article

Reciprocal regulation of two G protein-coupled receptors sensing extracellular concentrations of Ca2+ and H.

Abstract:

G protein-coupled receptors (GPCRs) are cell surface receptors that detect a wide range of extracellular messengers and convey this information to the inside of cells. Extracellular calcium-sensing receptor (CaSR) and ovarian cancer gene receptor 1 (OGR1) are two GPCRs that sense extracellular Ca(2+) and H(+), respectively. These two ions are key components of the interstitial fluid, and their concentrations change in an activity-dependent manner. Importantly, the interstitial fluid forms par...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1073/pnas.1506085112

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More from this funder
Funding agency for:
Glitsch, M
Publisher:
National Academy of Sciences Publisher's website
Journal:
Proceedings of the National Academy of Sciences Journal website
Volume:
112
Issue:
34
Pages:
10738–10743
Publication date:
2015-01-01
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Source identifiers:
538155
Language:
English
Keywords:
Pubs id:
pubs:538155
UUID:
uuid:395cc044-ec69-4012-9517-839f877bfa1b
Local pid:
pubs:538155
Deposit date:
2015-08-12

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