Journal article
Novel role of the IGF-1 receptor in endothelial function and repair: studies in endothelium-targeted IGF-1 receptor transgenic mice.
- Abstract:
-
We recently demonstrated that reducing IGF-1 receptor (IGF-1R) numbers in the endothelium enhances nitric oxide (NO) bioavailability and endothelial cell insulin sensitivity. In the present report, we aimed to examine the effect of increasing IGF-1R on endothelial cell function and repair. To examine the effect of increasing IGF-1R in the endothelium, we generated mice overexpressing human IGF-1R in the endothelium (human IGF-1R endothelium-overexpressing mice [hIGFREO]) under direction of th...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Authors
Funding
Medical Research Council
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British Heart Foundation
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Bibliographic Details
- Publisher:
- American Diabetes Association Publisher's website
- Journal:
- Diabetes Journal website
- Volume:
- 61
- Issue:
- 9
- Pages:
- 2359-2368
- Publication date:
- 2012-06-25
- Acceptance date:
- 2012-04-18
- DOI:
- EISSN:
-
1939-327X
- ISSN:
-
0012-1797
Item Description
- Language:
- English
- Keywords:
- UUID:
-
uuid:396eae77-dd2b-4b0a-b59d-95d6b2095146
- Local pid:
- pubs:341122
- Source identifiers:
-
341122
- Deposit date:
- 2013-11-16
Terms of use
- Copyright holder:
- American Diabetes Association
- Copyright date:
- 2012
- Notes:
-
Copyright © 2012 by the American Diabetes Association.
Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.
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