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A divergent CFTR homologue: highly regulated salt transport in the euryhaline teleost F. heteroclitus.

Abstract:

The killifish, Fundulus heteroclitus, is a euryhaline teleost fish capable of adapting rapidly to transfer from freshwater (FW) to four times seawater (SW). To investigate osmoregulation at a molecular level, a 5.7-kilobase cDNA homologous to human cystic fibrosis transmembrane conductance regulator (hCFTR) was isolated from a gill cDNA library from SW-adapted killifish. This cDNA encodes a protein product (kfCFTR) that is 59% identical to hCFTR, the most divergent form of CFTR characterized ...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MPLS
Department:
Physics
Sub department:
Condensed Matter Physics
Role:
Author
Journal:
American journal of physiology
Volume:
274
Issue:
3 Pt 1
Pages:
C715-C723
Publication date:
1998-03-01
ISSN:
0002-9513
Source identifiers:
8948

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