Journal article
Tyrosine 319 in the interdomain B of ZAP-70 is a binding site for the Src homology 2 domain of Lck.
- Abstract:
-
T-cell antigen receptor-induced signaling requires both ZAP-70 and Lck protein-tyrosine kinases. One essential function of Lck in this process is to phosphorylate ZAP-70 and up-regulate its catalytic activity. We have previously shown that after T-cell antigen receptor stimulation, Lck binds to ZAP-70 via its Src homology 2 (SH2) domain (LckSH2) and, more recently, that Tyr319 of ZAP-70 is phosphorylated in vivo and plays a positive regulatory role. Here, we investigated the possibility that ...
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- Publication status:
- Published
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- Publisher copy:
- 10.1074/jbc.274.20.14229
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Authors
Bibliographic Details
- Journal:
- Journal of biological chemistry
- Volume:
- 274
- Issue:
- 20
- Pages:
- 14229-14237
- Publication date:
- 1999-05-01
- DOI:
- EISSN:
-
1083-351X
- ISSN:
-
0021-9258
- Source identifiers:
-
17164
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:17164
- UUID:
-
uuid:39816780-b7b0-491f-bfe0-a178dd1c0b6e
- Local pid:
- pubs:17164
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 1999
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