Journal article icon

Journal article

Exploring the developmental overnutrition hypothesis using parental-offspring associations and FTO as an instrumental variable

Abstract:

Background: The developmental overnutrition hypothesis suggests that greater maternal obesity during pregnancy results in increased offspring adiposity in later life. If true, this would result in the obesity epidemic progressing across generations irrespective of environmental or genetic changes. It is therefore important to robustly test this hypothesis. Methods and Findings: We explored this hypothesis by comparing the associations of maternal and paternal prepregnancy body mass index (BMI...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1371/journal.pmed.0050033

Authors


More by this author
Institution:
University of Bristol
Department:
Department of Social Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
More by this author
Institution:
University of Bristol
Department:
Department of Social Medicine
Role:
Author
More by this author
Institution:
University of Bristol
Department:
Department of Oral and Dental Science
Role:
Author
More by this author
Institution:
University of Bristol
Department:
Department of Oral and Dental Science
Role:
Author
Expand authors...
Medical Research Council More from this funder
University of Bristol More from this funder
Wellcome Trust More from this funder
United States National Institutes of Health: National Institute of Diabetes and Digestive and Kidney Diseases More from this funder
Expand funders...
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Medicine Journal website
Volume:
5
Issue:
3
Article number:
e33
Publication date:
2008-03-01
DOI:
EISSN:
1549-1676
ISSN:
1549-1277
Language:
English
Keywords:
Subjects:
UUID:
uuid:3996ffdf-fc92-4cba-b840-ff9899fe9aba
Local pid:
ora:2518
Deposit date:
2009-01-09

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP