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Plasmodium falciparum antimalarial drug susceptibility on the north-western border of Thailand during five years of extensive use of artesunate-mefloquine.

Abstract:

Following a marked decline in the efficacy in vivo of mefloquine between 1990 and 1994, a combination of artesunate (4 mg/kg/d for 3 d) and mefloquine (25 mg/kg) has been used as first line treatment of uncomplicated falciparum malaria in camps for displaced persons located along the north-western border of Thailand. Antimalarial drug susceptibility of fresh isolates of Plasmodium falciparum from this population was evaluated using a radioisotope microdilution assay between 1995 and 1999. In ...

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Publication status:
Published

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Journal:
Transactions of the Royal Society of Tropical Medicine and Hygiene
Volume:
94
Issue:
5
Pages:
537-544
Publication date:
2000-01-01
DOI:
EISSN:
1878-3503
ISSN:
0035-9203
Source identifiers:
18583

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