Journal article
T cell receptors are structures capable of initiating signaling in the absence of large conformational rearrangements.
- Abstract:
-
Native and non-native ligands of the T cell receptor (TCR), including antibodies, have been proposed to induce signaling in T cells via intra- or intersubunit conformational rearrangements within the extracellular regions of TCR complexes. We have investigated whether any signatures can be found for such postulated structural changes during TCR triggering induced by antibodies, using crystallographic and mutagenesis-based approaches. The crystal structure of murine CD3ε complexed with the mit...
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- Publication status:
- Published
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- Publisher copy:
- 10.1074/jbc.m111.332783
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Authors
Bibliographic Details
- Journal:
- Journal of biological chemistry
- Volume:
- 287
- Issue:
- 16
- Pages:
- 13324-13335
- Publication date:
- 2012-04-01
- DOI:
- EISSN:
-
1083-351X
- ISSN:
-
0021-9258
- Source identifiers:
-
245837
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:245837
- UUID:
-
uuid:39a9f286-229a-48ab-b732-be2763b877a4
- Local pid:
- pubs:245837
- Deposit date:
- 2013-11-17
Terms of use
- Copyright date:
- 2012
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