Journal article icon

Journal article

T cell receptors are structures capable of initiating signaling in the absence of large conformational rearrangements.

Abstract:

Native and non-native ligands of the T cell receptor (TCR), including antibodies, have been proposed to induce signaling in T cells via intra- or intersubunit conformational rearrangements within the extracellular regions of TCR complexes. We have investigated whether any signatures can be found for such postulated structural changes during TCR triggering induced by antibodies, using crystallographic and mutagenesis-based approaches. The crystal structure of murine CD3ε complexed with the mit...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1074/jbc.m111.332783

Authors


Expand authors...
Journal:
Journal of biological chemistry
Volume:
287
Issue:
16
Pages:
13324-13335
Publication date:
2012-04-01
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
Source identifiers:
245837

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP