Journal article icon

Journal article

Kcnj16 (Kir5.1) gene ablation causes subfertility and increases the prevalence of morphologically abnormal spermatozoa

Abstract:

The ability of spermatozoa to swim towards an oocyte and fertilize it depends on precise K+ permeability changes. Kir5.1 is an inwardly-rectifying potassium (Kir) channel with high sensitivity to intracellular H+ (pHi) and extracellular K+ concentration [K+]o, and hence provides a link between pHi and [K+]o changes and membrane potential. The intrinsic pHi sensitivity of Kir5.1 suggests a possible role for this channel in the pHi-dependent processes that take place during fertilization. Howev...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.3390/ijms22115972

Authors


More by this author
Role:
Author
ORCID:
0000-0003-3359-8208
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Physics
Sub department:
Condensed Matter Physics
Oxford college:
Green Templeton College
Role:
Author
ORCID:
0000-0001-8996-2000
Expand authors...
College of Medicine and Health Sciences, United Arab Emirates University More from this funder
Publisher:
MDPI Publisher's website
Journal:
International Journal of Molecular Sciences Journal website
Volume:
22
Issue:
11
Article number:
5972
Place of publication:
Switzerland
Publication date:
2021-06-01
Acceptance date:
2021-05-27
DOI:
EISSN:
1422-0067
Pmid:
34205849
Language:
English
Keywords:
Pubs id:
1181568
Local pid:
pubs:1181568
Deposit date:
2021-07-22

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP