Journal article
Kcnj16 (Kir5.1) gene ablation causes subfertility and increases the prevalence of morphologically abnormal spermatozoa
- Abstract:
-
The ability of spermatozoa to swim towards an oocyte and fertilize it depends on precise K+ permeability changes. Kir5.1 is an inwardly-rectifying potassium (Kir) channel with high sensitivity to intracellular H+ (pHi) and extracellular K+ concentration [K+]o, and hence provides a link between pHi and [K+]o changes and membrane potential. The intrinsic pHi sensitivity of Kir5.1 suggests a possible role for this channel in the pHi-dependent processes that take place during fertilization. Howev...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
College of Medicine and Health Sciences, United Arab Emirates University
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Bibliographic Details
- Publisher:
- MDPI Publisher's website
- Journal:
- International Journal of Molecular Sciences Journal website
- Volume:
- 22
- Issue:
- 11
- Article number:
- 5972
- Place of publication:
- Switzerland
- Publication date:
- 2021-06-01
- Acceptance date:
- 2021-05-27
- DOI:
- EISSN:
-
1422-0067
- Pmid:
-
34205849
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
1181568
- Local pid:
- pubs:1181568
- Deposit date:
- 2021-07-22
Terms of use
- Copyright holder:
- Poli et al.
- Copyright date:
- 2021
- Rights statement:
- © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
- Licence:
- CC Attribution (CC BY)
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