An Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence.

Journal article

Here we describe a previously unknown form of inherited immunodeficiency revealed by an N-ethyl-N-nitrosourea-induced mutation called elektra. Mice homozygous for this mutation showed enhanced susceptibility to bacterial and viral infection and diminished numbers of T cells and inflammatory monocytes that failed to proliferate after infection and died via the intrinsic apoptotic pathway in response to diverse proliferative stimuli. They also had a greater proportion of T cells poised to repli...

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Authors: Berger, M; Krebs, P; Crozat, K; Li, X; Croker, B

• Journal: Nature immunology
• Volume: 11
• Issue: 4
• Pages: 335-343
• Publication date: 2010-04-01
• DOI: 10.1038/ni.1847
• EISSN: 1529-2916
• ISSN: 1529-2908
• Language: English
• Keywords: Mice, Transgenic; Animals; Cell Cycle Proteins; Phenotype; Flow Cytometry; Mice; Base Sequence; Apoptosis; Mutation; Cell Separation; T-Lymphocytes; Leukocytes, Mononuclear; Immunologic Deficiency Syndromes; Signal Transduction; Lymphocyte Activation