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Influence of propofol on isolated neonatal rat carotid body glomus cell response to hypoxia and hypercapnia

Abstract:

In humans the intravenous anaesthetic propofol depresses ventilatory responses to hypoxia and CO2. Animal studies suggest that this may in part be due to inhibition of synaptic transmission between chemoreceptor glomus cells of the carotid body and the afferent carotid sinus nerve. It is however unknown if propofol can also act directly on the glomus cell. Here we report that propofol can indeed inhibit intracellular Ca2+ responses to hypoxia and hypercapnia in isolated rat glomus cells. Neit...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.resp.2018.10.007

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Sub department:
Primary Care Health Sciences
Role:
Author
ORCID:
0000-0001-7299-8939
More by this author
Institution:
University of Oxford
Division:
MSD
Sub department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
Mason Medical Research Foundation More from this funder
Medical Research Council More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Respiratory Physiology and Neurobiology Journal website
Volume:
260
Issue:
February 2019
Pages:
17-27
Publication date:
2018-10-30
Acceptance date:
2018-10-29
DOI:
ISSN:
1569-9048
Pmid:
30389452
Language:
English
Keywords:
Pubs id:
943803
Local pid:
pubs:943803
Deposit date:
2020-10-30

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