Journal article
Steering evolution with sequential therapy to prevent the emergence of bacterial antibiotic resistance
- Abstract:
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The increasing rate of antibiotic resistance and slowing discovery of novel antibiotic treatments presents a growing threat to public health. Here, we consider a simple model of evolution in asexually reproducing populations which considers adaptation as a biased random walk on a fitness landscape. This model associates the global properties of the fitness landscape with the algebraic properties of a Markov chain transition matrix and allows us to derive general results on the non-commutativi...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Version of record, pdf, 878.8KB)
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- Publisher copy:
- 10.1371/journal.pcbi.1004493
Authors
Funding
Veterans Affairs Merit Review Program
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Bibliographic Details
- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PLoS Computational Biology Journal website
- Volume:
- 11
- Issue:
- 9
- Article number:
- e1004493
- Publication date:
- 2015-09-11
- Acceptance date:
- 2019-08-07
- DOI:
- EISSN:
-
1553-7358
- ISSN:
-
1553-734X
Item Description
- Language:
- English
- Pubs id:
-
pubs:571800
- UUID:
-
uuid:39c50aee-1ae7-4241-a792-8cd36d6bca03
- Local pid:
- pubs:571800
- Source identifiers:
-
571800
- Deposit date:
- 2016-02-27
Terms of use
- Copyright holder:
- None
- Copyright date:
- 2015
- Notes:
- This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication
- Licence:
- Other
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