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Plasmodium falciparum PfEMP1 modulates monocyte/macrophage transcription factor activation, and cytokine and chemokine responses

Abstract:

Immunity to Plasmodium falciparum malaria is slow to develop, and it is often asserted that malaria suppresses host immunity, although this is poorly understood and the molecular basis for such activity remains unknown. P. falciparum Erythrocyte Membrane Protein 1 (PfEMP1) is a virulence factor that plays a key role in parasite-host interactions. We investigated the immunosuppressive effect of PfEMP1 on monocytes/macrophages, which are central to the anti-parasitic innate response. RAW macrop...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1128/IAI.00447-17

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM, RDM - Investigative Medicine Division
Role:
Author
Publisher:
American Society for Microbiology Publisher's website
Journal:
Infection and Immunity Journal website
Volume:
86
Issue:
1
Pages:
e00447-17
Publication date:
2017-10-16
Acceptance date:
2017-10-03
DOI:
EISSN:
1098-5522
ISSN:
0019-9567
Source identifiers:
747044
Pubs id:
pubs:747044
UUID:
uuid:39c57326-e24d-4c93-8337-a231f279b18a
Local pid:
pubs:747044
Deposit date:
2017-11-20

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