Journal article
Plasmodium falciparum PfEMP1 modulates monocyte/macrophage transcription factor activation, and cytokine and chemokine responses
- Abstract:
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Immunity to Plasmodium falciparum malaria is slow to develop, and it is often asserted that malaria suppresses host immunity, although this is poorly understood and the molecular basis for such activity remains unknown. P. falciparum Erythrocyte Membrane Protein 1 (PfEMP1) is a virulence factor that plays a key role in parasite-host interactions. We investigated the immunosuppressive effect of PfEMP1 on monocytes/macrophages, which are central to the anti-parasitic innate response. RAW macrop...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 1.4MB)
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- Publisher copy:
- 10.1128/IAI.00447-17
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Authors
Bibliographic Details
- Publisher:
- American Society for Microbiology Publisher's website
- Journal:
- Infection and Immunity Journal website
- Volume:
- 86
- Issue:
- 1
- Pages:
- e00447-17
- Publication date:
- 2017-10-16
- Acceptance date:
- 2017-10-03
- DOI:
- EISSN:
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1098-5522
- ISSN:
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0019-9567
- Source identifiers:
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747044
Item Description
- Pubs id:
-
pubs:747044
- UUID:
-
uuid:39c57326-e24d-4c93-8337-a231f279b18a
- Local pid:
- pubs:747044
- Deposit date:
- 2017-11-20
Terms of use
- Copyright holder:
- Sampaio et al
- Copyright date:
- 2017
- Notes:
- © 2017 Sampaio et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.
- Licence:
- CC Attribution (CC BY)
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