Journal article icon

Journal article

Immune or genetic-mediated disruption of CASPR2 causes pain hypersensitivity due to enhanced primary afferent excitability

Abstract:

Human autoantibodies to contactin-associated protein-like 2 (CASPR2) are often associated with neuropathic pain, and CASPR2 mutations have been linked to autism spectrum disorders, in which sensory dysfunction is increasingly recognized. Human CASPR2 autoantibodies, when injected into mice, were peripherally restricted and resulted in mechanical pain-related hypersensitivity in the absence of neural injury. We therefore investigated the mechanism by which CASPR2 modulates nociceptive function...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1016/j.neuron.2018.01.033

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
Role:
Author
Expand authors...
More from this funder
Funding agency for:
Bennett, D
Grant:
202747/Z/16/Z
Publisher:
Elsevier Publisher's website
Journal:
Neuron Journal website
Volume:
97
Issue:
4
Pages:
806-822.e10
Publication date:
2018-02-08
Acceptance date:
2018-01-12
DOI:
EISSN:
1097-4199
ISSN:
0896-6273
Source identifiers:
823405
Pubs id:
pubs:823405
UUID:
uuid:39c91468-de57-45e1-a764-c919122c13df
Local pid:
pubs:823405
Deposit date:
2018-02-09

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP