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Journal article

Interaction of Avibactam with Class B Metallo-β-Lactamases.

Abstract:

β-Lactamases are the most important mechanisms of resistance to the β-lactam antibacterials. There are two mechanistic classes of β-lactamases: the serine β-lactamases (SBLs) and the zinc-dependent metallo-β-lactamases (MBLs). Avibactam, the first clinically useful non-β-lactam β-lactamase inhibitor, is a broad-spectrum SBL inhibitor, which is used in combination with a cephalosporin antibiotic (ceftazidime). There are multiple reports on the interaction of avibactam with SBLs but few such st...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1128/AAC.00897-16

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
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Biochemical Society Krebs Memorial Award More from this funder
Wellcome Trust More from this funder
AstraZeneca More from this funder
Publisher:
American Society for Microbiology Publisher's website
Journal:
Antimicrobial Agents and Chemotherapy Journal website
Volume:
60
Issue:
10
Pages:
5655-5662
Publication date:
2016-07-11
Acceptance date:
2016-07-05
DOI:
ISSN:
1098-6596 and 0066-4804
Pmid:
27401561
Source identifiers:
634073
Language:
English
Keywords:
Pubs id:
pubs:634073
UUID:
uuid:39ca146b-51ad-4d4c-b8be-9987b578ad4e
Local pid:
pubs:634073
Deposit date:
2016-11-03

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