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Journal article

Identification of the residues in human CD4 critical for the binding of HIV.

Abstract:

The CD4 molecule is a T cell surface glycoprotein that interacts with high affinity with the envelope glycoprotein of the human immunodeficiency virus, HIV, thus serving as a cellular receptor for this virus. To define the sites on CD4 essential for binding to gp120, we produced several truncated, soluble derivatives of CD4 and a series of 26 substitution mutants. Quantitative binding analyses with the truncated proteins demonstrate that the determinants for high affinity binding lie solely w...

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Publication status:
Published

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Journal:
Cell
Volume:
57
Issue:
3
Pages:
469-481
Publication date:
1989-05-01
DOI:
EISSN:
1097-4172
ISSN:
0092-8674
Source identifiers:
21214

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