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Journal article

The magnitude and breadth of hepatitis C virus-specific CD8+ T cells depend on absolute CD4+ T-cell count in individuals coinfected with HIV-1.

Abstract:

CD8(+) T-cell responses are an essential antiviral host defense in persistent viral infections, and their sustained effectiveness is thought to be critically dependent on CD4(+) T-helper cells. To determine the relationship between HIV-1-induced CD4(+) T-cell depletion and hepatitis C virus (HCV)-specific CD8(+) T-cell responses during viral persistence, we studied 103 persons positive for HCV, 74 coinfected with HIV-1. CD8(+) T-cell responses to the entire HCV polyprotein were determined by ...

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Publication status:
Published

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Publisher copy:
10.1182/blood-2004-06-2336

Authors


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Journal:
Blood
Volume:
105
Issue:
3
Pages:
1170-1178
Publication date:
2005-02-01
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
Source identifiers:
16911
Language:
English
Keywords:
Pubs id:
pubs:16911
UUID:
uuid:39f1baab-df81-4670-89c9-766ef821cbbc
Local pid:
pubs:16911
Deposit date:
2012-12-19

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