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Neisseria cinerea Expresses a Functional Factor H Binding Protein Which Is Recognized by Immune Responses Elicited by Meningococcal Vaccines

Abstract:

Neisseria meningitidis is a major cause of bacterial meningitis and sepsis worldwide. Capsular polysaccharide vaccines are available against meningococcal serogroups A, C, W, and Y. More recently two protein-based vaccines, Bexsero and Trumenba, against meningococcal serogroup B strains have been licensed; both vaccines contain meningococcal factor H binding protein (fHbp). fHbp is a surface-exposed lipoprotein that binds the negative complement regulator complement factor H (CFH), thereby i...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1128/IAI.00305-17

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Oxford college:
Exeter College
Role:
Author

Contributors

Role:
Editor
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Funding agency for:
Tang, C
Grant:
G12867
More from this funder
Funding agency for:
Tang, C
Grant:
G12867
Publisher:
American Society for Microbiology Publisher's website
Journal:
Infection and Immunity Journal website
Volume:
85
Issue:
10
Pages:
e00305-17
Publication date:
2017-07-24
Acceptance date:
2017-07-07
DOI:
EISSN:
1098-5522
ISSN:
0019-9567
Source identifiers:
731865
Keywords:
Pubs id:
pubs:731865
UUID:
uuid:39f29882-ea33-4f8c-98c1-f65f2df304b6
Local pid:
pubs:731865
Deposit date:
2017-10-04

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