Metabolomic characterisation of acidosis in severe falciparum malaria

Thesis

Severe falciparum malaria is a potentially lethal parasitic infection for which the treatment remains suboptimal as the pathophysiology is incompletely understood. Acidosis is the strongest predictor of death, caused by an accumulation of acids of which some are known, such as L-lactate, while others remain unidentified. The aim of this thesis was to further characterise metabolic acidosis in severe falciparum malaria by establishing the identity and source of the unidentified non-lactate...

Expand abstract

Authors: Leopold, S

• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford
• Language: English
• Keywords: Pathophysiology; Metabolomics; Plasmodium falciparum; Gut microbiota
• Subjects: Malaria