Journal article
Emergence of a distinct HIV-specific IL-10-producing CD8+ T-cell subset with immunomodulatory functions during chronic HIV-1 infection.
- Abstract:
-
Interleukin-10 (IL-10) plays a key role in regulating proinflammatory immune responses to infection but can interfere with pathogen clearance. Although IL-10 is upregulated throughout HIV-1 infection in multiple cell subsets, whether this is a viral immune evasion strategy or an appropriate response to immune activation is unresolved. Analysis of IL-10 production at the single cell level in 51 chronically infected subjects (31 antiretroviral (ART) naïve and 20 ART treated) showed that a subse...
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- Publication status:
- Published
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- Publisher copy:
- 10.1002/eji.201343646
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Bibliographic Details
- Journal:
- European journal of immunology
- Volume:
- 43
- Issue:
- 11
- Pages:
- 2875-2885
- Publication date:
- 2013-11-01
- DOI:
- EISSN:
-
1521-4141
- ISSN:
-
0014-2980
- Source identifiers:
-
416267
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:416267
- UUID:
-
uuid:3a15920e-5a7b-44de-9f48-fdcfffb2cabc
- Local pid:
- pubs:416267
- Deposit date:
- 2013-11-16
Terms of use
- Copyright date:
- 2013
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