Electrophysiological characterization of the human two-pore channel 2

Thesis

The Two-pore channel (TPC1-3) family represents a recently identified class of endolysosomal ion channels. TPCs were originally proposed to be promising candidate channels for NAADP-induced Ca²⁺ release. However, subsequent studies have emerged to propose an alternative view where TPCs may be Na+-selective channels regulated by the lysosome-specific phosphoinositide PI(3,5)P2 or voltage in an isoform-dependent manner. This thesis asks the question of whether pharmacological and ...

Expand abstract

Authors: Lam, A

• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford
• Language: English
• Keywords: Intracellular channel blocker; Ion permeation mechanisms; Equilibrium ion selectivity; Fractional Ca2+ current; Ion transport selectivity; Two-pore channels
• Subjects: Ion channel biophysics; Electrophysiology; Pharmacology