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Journal article

NGF-TrkA signaling by sensory nerves coordinates the vascularization and ossification of developing endochondral bone

Abstract:

Developing tissues dictate the amount and type of innervation they require by secreting neurotrophins, which promote neuronal survival by activating distinct tyrosine kinase receptors. Here, we show that nerve growth factor (NGF) signaling through neurotrophic tyrosine kinase receptor type 1 (TrkA) directs innervation of the developing mouse femur to promote vascularization and osteoprogenitor lineage progression. At the start of primary ossification, TrkA-positive axons were observed at peri...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.celrep.2016.08.002

Authors


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Department of Veterans Affairs More from this funder
Craig H. Neilsen Foundation More from this funder
Publisher:
Cell Press Publisher's website
Journal:
Cell Reports Journal website
Volume:
16
Issue:
10
Pages:
2723-2735
Publication date:
2016-08-25
Acceptance date:
2016-07-31
DOI:
ISSN:
2211-1247
Source identifiers:
641562
Keywords:
Pubs id:
pubs:641562
UUID:
uuid:3a1d9fe8-20e3-4635-99a3-3b9fbe4b185c
Local pid:
pubs:641562
Deposit date:
2016-09-05

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