Journal article
Atypical activation of the unfolded protein response in cystic fibrosis airway cells contributes to p38 MAPK-mediated innate immune responses.
- Abstract:
-
Inflammatory lung disease is the major cause of morbidity and mortality in cystic fibrosis (CF); understanding what produces dysregulated innate immune responses in CF cells will be pivotal in guiding the development of novel anti-inflammatory therapies. To elucidate the molecular mechanisms that mediate exaggerated inflammation in CF following TLR signaling, we profiled global gene expression in immortalized human CF and non-CF airway cells at baseline and after microbial stimulation. Using ...
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- Publisher copy:
- 10.4049/jimmunol.1103661
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Authors
Bibliographic Details
- Journal:
- Journal of Immunology
- Volume:
- 189
- Issue:
- 11
- Pages:
- 5467-5475
- Publication date:
- 2012-12-01
- DOI:
- EISSN:
-
1550-6606
- ISSN:
-
0022-1767
- Source identifiers:
-
367380
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:367380
- UUID:
-
uuid:3a2286e1-9ab5-4086-8d97-721b2888e661
- Local pid:
- pubs:367380
- Deposit date:
- 2013-11-17
Terms of use
- Copyright date:
- 2012
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