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Atypical activation of the unfolded protein response in cystic fibrosis airway cells contributes to p38 MAPK-mediated innate immune responses.

Abstract:

Inflammatory lung disease is the major cause of morbidity and mortality in cystic fibrosis (CF); understanding what produces dysregulated innate immune responses in CF cells will be pivotal in guiding the development of novel anti-inflammatory therapies. To elucidate the molecular mechanisms that mediate exaggerated inflammation in CF following TLR signaling, we profiled global gene expression in immortalized human CF and non-CF airway cells at baseline and after microbial stimulation. Using ...

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Publisher copy:
10.4049/jimmunol.1103661

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Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Role:
Author
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Journal:
Journal of Immunology
Volume:
189
Issue:
11
Pages:
5467-5475
Publication date:
2012-12-01
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
Source identifiers:
367380

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