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Studies towards the total synthesis of tetrodecamycin

Abstract:

Tetrodecamycin (1) is a novel α-(𝛾-hydroxyacyl) tetronic acid based polyketide antibiotic isolated from the culture broth of Streptomyces nashvillensis MJ885-mF8 by Takeuchi et al. in 1994. Compound 1 shows potent inhibitory activity against Gram-positive bacteria including Bacillus anthracis and methicillin resistant Staphylococcus aureus (MRSA).

It was proposed that an Aldol reaction of trans-decalin core 2 and tetronic acid derivative...

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Institution:
University of Oxford
Division:
MPLS
Role:
Author

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Role:
Supervisor
Role:
Supervisor
Publication date:
2007
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Source identifiers:
603858265
Language:
English
Subjects:
UUID:
uuid:3a2ab5cb-2757-4e53-b8cf-c635aef99455
Local pid:
td:603858265
Deposit date:
2013-06-22

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