Thesis
Studies towards the total synthesis of tetrodecamycin
- Abstract:
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Tetrodecamycin (1) is a novel α-(𝛾-hydroxyacyl) tetronic acid based polyketide antibiotic isolated from the culture broth of Streptomyces nashvillensis MJ885-mF8 by Takeuchi et al. in 1994. Compound 1 shows potent inhibitory activity against Gram-positive bacteria including Bacillus anthracis and methicillin resistant Staphylococcus aureus (MRSA).
It was proposed that an Aldol reaction of trans-decalin core 2 and tetronic acid derivative...
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Bibliographic Details
- Publication date:
- 2007
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- Source identifiers:
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603858265
Item Description
- Language:
- English
- Subjects:
- UUID:
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uuid:3a2ab5cb-2757-4e53-b8cf-c635aef99455
- Local pid:
- td:603858265
- Deposit date:
- 2013-06-22
Terms of use
- Copyright holder:
- He, J
- Copyright date:
- 2007
- Notes:
- The digital copy of this thesis has been made available thanks to the generosity of Dr Leonard Polonsky
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