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Journal article

The combination of tamoxifen with amphotericin B, but not with fluconazole, has synergistic activity against the majority of clinical isolates of Cryptococcus neoformans

Abstract:

Background Cryptococcal meningitis has fatality rates of 40%‐70%, resulting in 200 000 deaths each year. The best outcomes are achieved with amphotericin combined with flucytosine but flucytosine is expensive and unavailable where most disease occurs. More effective and affordable treatments are needed. Tamoxifen, a selective oestrogen receptor modulator frequently indicated for breast cancer, has been found to have synergistic activity against the Cryptococcus neoform...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1111/myc.12955

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Publisher:
Wiley Publisher's website
Journal:
Mycoses Journal website
Volume:
62
Issue:
9
Pages:
818-825
Publication date:
2019-06-07
Acceptance date:
2019-06-04
DOI:
EISSN:
1439-0507
ISSN:
0933-7407
Source identifiers:
1009286
Keywords:
Pubs id:
pubs:1009286
UUID:
uuid:3a41f1cd-c7f8-4c9e-9caf-98b5d87c875a
Local pid:
pubs:1009286
Deposit date:
2019-06-07

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