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Requirement of mature dendritic cells for efficient activation of influenza A-specific memory CD8+ T cells.

Abstract:

It is critical to identify the developmental stage of dendritic cells (DCs) that is most efficient at inducing CD8+ T cell responses. Immature DCs can be generated from monocytes with GM-CSF and IL-4, while maturation is accomplished by the addition of stimuli such as monocyte-conditioned medium, CD40 ligand, and LPS. We evaluated the ability of human monocytes and immature and mature DCs to induce CD8+ effector responses to influenza virus Ags from resting memory cells. We studied replicatin...

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Publication status:
Published

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Publisher copy:
10.4049/jimmunol.165.3.1182

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Journal:
Journal of Immunology
Volume:
165
Issue:
3
Pages:
1182-1190
Publication date:
2000-08-01
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
Source identifiers:
31720

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