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Journal article

Identification of Annexina1 as an endogenous regulator of RhoA, and its role in the pathophysiology and experimental therapy of type-2 diabetes

Abstract:

Annexin A1 (ANXA1) is an endogenously produced anti-inflammatory protein, which plays an important role in the pathophysiology of diseases associated with chronic inflammation. We demonstrate that patients with type-2 diabetes have increased plasma levels of ANXA1 when compared to normoglycemic subjects. Plasma ANXA1 positively correlated with fatty liver index and elevated plasma cholesterol in patients with type-2 diabetes, suggesting a link between aberrant lipid handling, and ANXA1. Us...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.3389/fimmu.2019.00571

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
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Publisher:
Frontiers Media Publisher's website
Journal:
Frontiers in Immunology Journal website
Volume:
10
Article number:
571
Publication date:
2019-03-27
Acceptance date:
2019-03-04
DOI:
EISSN:
1664-3224
Source identifiers:
1033380
Keywords:
Pubs id:
pubs:1033380
UUID:
uuid:3a59c548-763e-4b90-bea8-4b1bb629b6ed
Local pid:
pubs:1033380
Deposit date:
2019-07-18

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